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SPONTANEOUS ALLOZYME MUTATIONS IN DROSOPHILA MELANOGASTER: RATE OF OCCURRENCE AND NATURE OF THE MUTANTS
Robert A. Voelker 1, Henry E. Schaffer 1, and Terumi Mukai 1
1 Department of Genetics, North Carolina State University, Raleigh, North Carolina 27607
After additional generations of accumulation of allozyme mutants, the 1,000 lines of Mukai and Cockerham (1977) were again screened for the same five loci (
-Gpdh, cMdh, Adh, Hex-C and -Amy), as well as for two new loci (Got-2 and Dip-A). Based on 3,111,598 allele generations: (1) the average mutation rate to new mobility variants with normal function was estimated to be 1.28 x 10-6, and (2) the average mutation rate to null alleles was estimated to be 3.86 x 10-6. A qualitative analysis of the nulls provided evidence that most of the mutants recovered are due to base substitutions. No apparent correlation was observed between structural gene size and mutation rate.
Revised on November 6, 1979
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