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DEPENDENCE ON MATING TYPE FOR THE OVERPRODUCTION OF ISO-2-CYTOCHROME c IN THE YEAST MUTANT CYC7H2
Rodney J. Rothstein 1 and Fred Sherman 2
1 Department of Radiation Biology, University of Rochester School of Medicine and Dentistry, Rochester, N. Y. 14642
2 Department of Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, N. Y. 14642
The CYC7H2 mutation causes an approximately 20-fold overproduction of iso2cytochromo c in a and
haploid strains of the yeast Saccharomyces cerevisiae due to an alteration in the nontranslated regulatory region that is presumably contiguous with the structural region. In this investigation, we demonstrated that heterozygosity at the mating type locus, a/
or a/a/
/
, prevents expression of the overproduction, while homozygosity, a/a and
/
, and hemizygosity, a/0 and
/0, allow full expression of the CYC7H2 mutation, equivalent to the expression observed in a and
haploid strains. There is no decrease in the overproduction of iso-2-cytochrome c in a/
diploid strains containing either of the other two similar mutations, CYC7H1 and CYC7H3. It appears as if active expression of one or another of the mating-type alleles is required for the overproduction of iso-2-cytochrome c in CYC7H2 mutants.
Revised on October 29, 1979
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