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MITOTIC RECOMBINATION IN YEAST: ISOLATION AND CHARACTERIZATION OF MUTANTS WITH ENHANCED SPONTANEOUS MITOTIC GENE CONVERSION RATES
Daniel H. Maloney 1 and Seymour Fogel 1
1 Department of Genetics, University of California, Berkeley, California 94720
Semi-dominant mutants displaying greatly elevated (up to 200-fold above control) levels of spontaneous mitotic recombination have been isolated in a disomic haploid strain of yeast heteroallelic at the arg4 locus. They are designated by the symbol MIC. The mutants variously exhibit associated sensitivity to UV and ionizing radiation and to methyl methanesulfonate, enhanced UV-induced mitotic recombination, and enhanced spontaneous forward mutation rates. Possible enzyme defects and involvement in repair and editing of DNA are discussed. The mutants are expected to simplify the analysis of recombination pathways in yeast.
Submitted on March 19, 1979Revised on December 4, 1979
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