EFFECT OF TERMINAL ANEUPLOIDY ON EPIDERMAL CELL VIABILITY IN DROSOPHILA MELANOGASTER

Pedro Ripoll 1

1 Department of Biology, University of California, San Diego, La Jolla, California 92093

In Drosophila melanogaster, individuals heterozygous for translocations between chromosomes Y and 3 can generate, by means of mitotic recombination, somatic cells bearing duplications and deletions. Using translocations with different breakpoints, I have studied the behavior of clones of cells with increasing degrees of aneuploidy in the abdominal cuticle. Both hyper- and hypoploid cells can survive being duplicated or deficient even for large chromosome 3 fragments. While hyperploidy does not severely affect cell viability, the recovery of hypoploid clones decreases linearly as a function of the size of the deleted fragment. In this report, the quantitative and qualitative aspects of this effect are discussed.

Submitted on January 30, 1979
Revised on July 17, 1979




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