CYTOGENETIC ANALYSIS OF CHROMOSOME 3 IN DROSOPHILA MELANOGASTER: THE HOMOEOTIC GENE COMPLEX IN POLYTENE CHROMOSOME INTERVAL 84A-B

CYTOGENETIC ANALYSIS OF CHROMOSOME 3 IN DROSOPHILA MELANOGASTER: THE HOMOEOTIC GENE COMPLEX IN POLYTENE CHROMOSOME INTERVAL 84A-B

Thomas C. Kaufman ¹, Ricki Lewis ¹, and Barbara Wakimoto ¹

¹ Department of Biology, Indiana University, Bloomington, Indiana 47405

Cytogenetic evidence is presented demonstrating that the 84A-Binterval in the proximal portion of the right arm of chromosome3 is the residence of a homoeotic gene complex similar to thebithorax locus. This complex, originally defined by the Antennapedia(Antp) mutation, controls segmentation in the anterior portionof the organism. Different lesions within this complex homoeoticallytransform portions of the prothorax, proboscis, antenna andeye and present clear analogies to similar lesions within thebithorax locus.

Submitted on January 1, 1979
Revised on July 26, 1979

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				B. Rogers, M. Peterson, and T. Kaufman Evolution of the insect body plan as revealed by the Sex combs reduced expression pattern Development, January 1, 1997; 124(1): 149 - 157. [Abstract] [PDF]

				E. Carrington and R. Jones The Drosophila Enhancer of zeste gene encodes a chromosomal protein: examination of wild-type and mutant protein distribution Development, January 12, 1996; 122(12): 4073 - 4083. [Abstract] [PDF]

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				J Muller, S Gaunt, and P. Lawrence Function of the Polycomb protein is conserved in mice and flies Development, January 9, 1995; 121(9): 2847 - 2852. [Abstract] [PDF]

				J Castelli-Gair and M Akam How the Hox gene Ultrabithorax specifies two different segments: the significance of spatial and temporal regulation within metameres Development, January 9, 1995; 121(9): 2973 - 2982. [Abstract] [PDF]

				A Chiang, M. O'Connor, R Paro, J Simon, and W Bender Discrete Polycomb-binding sites in each parasegmental domain of the bithorax complex Development, January 6, 1995; 121(6): 1681 - 1689. [Abstract] [PDF]

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CYTOGENETIC ANALYSIS OF CHROMOSOME 3 IN DROSOPHILA MELANOGASTER: THE HOMOEOTIC GENE COMPLEX IN POLYTENE CHROMOSOME INTERVAL 84A-B

Thomas C. Kaufman 1, Ricki Lewis 1, and Barbara Wakimoto 1

Thomas C. Kaufman ¹, Ricki Lewis ¹, and Barbara Wakimoto ¹

				J Castelli-Gair, S Greig, G Micklem, and M Akam Dissecting the temporal requirements for homeotic gene function Development, January 7, 1994; 120(7): 1983 - 1995. [Abstract] [PDF]

				M O Fauvarque and J M Dura polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila. Genes & Dev., August 1, 1993; 7(8): 1508 - 1520. [Abstract] [PDF]

				B Jones and W McGinnis The regulation of empty spiracles by Abdominal-B mediates an abdominal segment identity function. Genes & Dev., February 1, 1993; 7(2): 229 - 240. [Abstract] [PDF]

				W Zeng, D. Andrew, L. Mathies, M. Horner, and M. Scott Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity Development, January 6, 1993; 118(2): 339 - 352. [Abstract] [PDF]

				B Jones and W McGinnis A new Drosophila homeobox gene, bsh, is expressed in a subset of brain cells during embryogenesis Development, January 2, 1993; 117(2): 793 - 806. [Abstract] [PDF]

				K Schneitz, P Spielmann, and M Noll Molecular genetics of aristaless, a prd-type homeo box gene involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages in Drosophila. Genes & Dev., January 1, 1993; 7(1): 114 - 129. [Abstract] [PDF]

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				S Messmer, A Franke, and R Paro Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster. Genes & Dev., July 1, 1992; 6(7): 1241 - 1254. [Abstract] [PDF]

				U Grossniklaus, R K Pearson, and W J Gehring The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors. Genes & Dev., June 1, 1992; 6(6): 1030 - 1051. [Abstract] [PDF]

				M DeCamillis, N S Cheng, D Pierre, and H W Brock The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome-binding sites with Polycomb. Genes & Dev., February 1, 1992; 6(2): 223 - 232. [Abstract] [PDF]