EVOLUTIONARY CONSERVATION OF EQUINE Gc ALLELES AND OF MAMMALIAN Gc/ALBUMIN LINKAGE

Lowell R. Weitkamp ¹ and Peter Z. Allen ²

¹ Department of Psychiatry, Division of Genetics and Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York
² Department of Microbiology, University of Rochester School of Medicine and Dentistry, Rochester, New York

Ancient origin of the equine vitamin D binding protein (Gc) polymorphism is suggested by the finding of two alleles, Gc^F and Gc^S, in each of three equine subgenera, Equus, Asinus and Hippotigris. The equine Gc and albumin loci are closely linked (lod score = 6). Although no recombinants were observed, the data are not inconsistent with a map distance similar to the 2 centimorgans reported for the human albumin/Gc linkage relationship. Gametic association between the Gc^F and Alb^F alleles appears probable in the American Standardbred horse, perhaps as a result of population structure. Since Gc and albumin are both polymorphic in rodents and possibly other orders, this linkage group will be useful for studies of the evolution of mammalian linkage groups, as well as for a comparison of meiotic recombination frequencies and linkage disequilibria in different species.