- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Zouros, E.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Zouros, E.
MUTATION RATES, POPULATION SIZES AND AMOUNTS OF ELECTROPHORETIC VARIATION OF ENZYME LOCI IN NATURAL POPULATIONS
E. Zouros 1
1 Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
A method is presented for estimating relative mutation rates or relative effective population sizes, under the hypothesis of adaptively neutral allelic variation. This method was applied to seven surveys of electrophoretic variation. It was observed that electrophoretic mutation rates so obtained follow the gamma distribution and, in Drosophila, are positively correlated with the molecular weights of the enzyme subunits. The variance in mutation rate is larger under the step-wise model of electrophoretic mutation than under the infinite-alleles model. Rates for the most variable loci may exceed rates for less variable loci by a factor of 500. For completely invariant loci, this factor may be as high as 4 x 104, an observation suggesting that these loci are subject to purifying selection. In contrast to mutation rates, effective population sizes may vary at the most by a factor of ten. These results support the hypothesis that differences in the amount of electrophoretic variability among polymorphic loci may reflect differences in the rate by which electrophoretically detectable variation is generated in populations.
Submitted on January 31, 1978Revised on September 12, 1978
This article has been cited by other articles:
 |
|
 |
|
  A.-C. Thuillet, T. Bataillon, S. Poirier, S. Santoni, and J. L. David Estimation of Long-Term Effective Population Sizes Through the History of Durum Wheat Using Microsatellite Data Genetics, March 1, 2005; 169(3): 1589 - 1599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Xu and Y.-X. Fu Estimating Effective Population Size or Mutation Rate With Microsatellites Genetics, January 1, 2004; 166(1): 555 - 563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sivasundar and J. Hey Population Genetics of Caenorhabditis elegans: The Paradox of Low Polymorphism in a Widespread Species Genetics, January 1, 2003; 163(1): 147 - 157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Chakraborty, M. Kimmel, D. N. Stivers, L. J. Davison, and R. Deka Relative mutation rates at di-, tri-, and tetranucleotide microsatellite loci PNAS, February 4, 1997; 94(3): 1041 - 1046. [Abstract] [Full Text] [PDF]
|
|