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AN UNSTABLE NUCLEAR GENE IN PHYCOMYCES
M. Delbrück 1 and T. Ootaki 2
1 Division of Biology, California Institute of Technology, Pasadena, California 91125
2 Department of Biology, Education Faculty, Yamagata University, Yamagata, Japan 990
A gentic instability in Phycomyces is described that appears to be associated with a single nuclear gene, dar. The wild type is able to take up riboflavin and its toxic analogue, deaza-riboflavin, from nanomolar concentrations in the medium. The mutants are unable to take up riboflavin and are resistant to deaza-riboflavin. Forward and reverse mutation rates are estimated to be 4 x 10-5 and 2 x 10-3 per nuclear division. Independently arisen dar mutants do not complement in heterokaryons. The mutant alleles are almost completely recessive. The phenotype of spores is not determined cell-autonomously, but is strongly influenced by the allele ratio among the nuclei in the sporangium of origin.
Submitted on February 17, 1978Revised on September 15, 1978
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