- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Hansche, P. E.
- Articles by Lange, P.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Hansche, P. E.
- Articles by Lange, P.
GENE DUPLICATION IN SACCHAROMYCES CEREVISIAE
P. E. Hansche 1, V. Beres 1, and P. Lange 2
1 Department of Genetics, University of California, Davis, California
95616
2 Lehrstuhl für Genetik, Institut für Biologie, Universität
Tübingen, 7400 Tübingen, West Germany
Five indepdendent duplications of the acid-phosphatase (aphtase) structural gene (acp1) were recovered from chemostat populations of S. cerevisiae that were subject to selection for in vivo hyper-aphtase activity. Two of the duplications arose spontaneously. Three of them were induced by UV. All five of the duplication events involved the transpositioning of the aphtase structural gene, acp1, and all known genes distal to acp1 on the right arm of chromosome II, to the terminus of an arm of other unknown chromosomes. One of the five duplicated regions of the right arm of chromosome II was found to be transmitted mitotically and meiotically with very high fidelity. The other four duplicated regions of the right arm of chromosome II were found to be unstable, being lost at a rate of about 2% per mitosis. However, selection for increased fidelity of mitotic transmission was effective in one of these strains. No tandem duplications of the aphtase structural gene were found.
Submitted on July 12, 1977Revised on December 5, 1977
This article has been cited by other articles:
 |
|
 |
|
  R. Koszul, B. Dujon, and G. Fischer Stability of Large Segmental Duplications in the Yeast Genome Genetics, April 1, 2006; 172(4): 2211 - 2222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Schacherer, Y. Tourrette, J.-L. Souciet, S. Potier, and J. de Montigny Recovery of a Function Involving Gene Duplication by Retroposition in Saccharomyces cerevisiae Genome Res., July 1, 2004; 14(7): 1291 - 1297. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Dunham, H. Badrane, T. Ferea, J. Adams, P. O. Brown, F. Rosenzweig, and D. Botstein Characteristic genome rearrangements in experimental evolution of Saccharomycescerevisiae PNAS, December 10, 2002; 99(25): 16144 - 16149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nosaka, M. Onozuka, H. Nishino, H. Nishimura, Y. Kawasaki, and H. Ueyama Molecular Cloning and Expression of a Mouse Thiamin Pyrophosphokinase cDNA J. Biol. Chem., November 26, 1999; 274(48): 34129 - 34133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. Patterson, E. B. Albrecht, P. Nurse, S. Sazer, and G. R. Stark Effects of Genome Position and the DNA Damage Checkpoint on the Structure and Frequency of sod2 Gene Amplification in Fission Yeast Mol. Biol. Cell, July 1, 1999; 10(7): 2199 - 2208. [Abstract] [Full Text]
|
|