THE HOMOZYGOSITY TEST OF NEUTRALITY

G. A. Watterson ¹

¹ Monash University, Victoria 3168, Australia

An earlier paper showed that the homozygosity (of a population or sample) was a good statistic for testing departures from selective neutrality in the direction of heterozygote advantage or disadvantage. It is here shown that homozygosity is also influenced by the presence of deleterious alleles and by other departures from neutrality, but at a lower order of magnitude of effect if the selection coefficients are of the same small order of magnitude. Tables are provided for the significance points and moments of the homozygosity, under the null hypothesis of neutrality.

This article has been cited by other articles:

				N. A. Rosenberg and M. Jakobsson The Relationship Between Homozygosity and the Frequency of the Most Frequent Allele Genetics, August 1, 2008; 179(4): 2027 - 2036. [Abstract] [Full Text] [PDF]

				W. J Ewens Commentary: On Haldane's 'defense of beanbag genetics' Int. J. Epidemiol., June 1, 2008; 37(3): 447 - 451. [Full Text] [PDF]

				K. S. Kim, S. T. Ratcliffe, B. W. French, L. Liu, and T. W. Sappington Utility of EST-Derived SSRs as Population Genetics Markers in a Beetle J. Hered., March 1, 2008; 99(2): 112 - 124. [Abstract] [Full Text] [PDF]

				J. J. Cai PGEToolbox: A Matlab Toolbox for Population Genetics and Evolution J. Hered., February 29, 2008; (2008) esm127v1. [Abstract] [Full Text] [PDF]

				B. Star, R. J. Stoffels, and H. G. Spencer Evolution of Fitnesses and Allele Frequencies in a Population With Spatially Heterogeneous Selection Pressures Genetics, November 1, 2007; 177(3): 1743 - 1751. [Abstract] [Full Text] [PDF]

				K. Zeng, S. Shi, and C.-I Wu Compound Tests for the Detection of Hitchhiking Under Positive Selection Mol. Biol. Evol., August 1, 2007; 24(8): 1898 - 1908. [Abstract] [Full Text] [PDF]

				B. Star, R. J. Stoffels, and H. G. Spencer Single-Locus Polymorphism in a Heterogeneous Two-Deme Model Genetics, July 1, 2007; 176(3): 1625 - 1633. [Abstract] [Full Text] [PDF]

				K. Zeng, S. Mano, S. Shi, and C.-I Wu Comparisons of Site- and Haplotype-Frequency Methods for Detecting Positive Selection Mol. Biol. Evol., July 1, 2007; 24(7): 1562 - 1574. [Abstract] [Full Text] [PDF]

				W. S. Grant, I. B. Spies, and M. F. Canino Biogeographic Evidence for Selection on Mitochondrial DNA in North Pacific Walleye Pollock Theragra chalcogramma J. Hered., November 1, 2006; 97(6): 571 - 580. [Abstract] [Full Text] [PDF]

				A. M. Casa, S. E. Mitchell, J. D. Jensen, M. T. Hamblin, A. H. Paterson, C. F. Aquadro, and S. Kresovich Evidence for a Selective Sweep on Chromosome 1 of Cultivated Sorghum Crop Sci., November 1, 2006; 46(Supplement_1): S-27 - S-40. [Abstract] [Full Text] [PDF]

				F. Oliva-Tejera, J. Caujape-Castells, J. Navarro-Deniz, A. Reyes-Betancort, S. Scholz, M. Baccarani-Rosas, and N. Cabrera-Garcia Patterns of genetic divergence of three Canarian endemic Lotus (Fabaceae): implications for the conservation of the endangered L. kunkelii Am. J. Botany, August 1, 2006; 93(8): 1116 - 1124. [Abstract] [Full Text] [PDF]

				D. Meyer, R. M. Single, S. J. Mack, H. A. Erlich, and G. Thomson Signatures of Demographic History and Natural Selection in the Human Major Histocompatibility Complex Loci Genetics, August 1, 2006; 173(4): 2121 - 2142. [Abstract] [Full Text] [PDF]

				M. Vos and G. J. Velicer Genetic Population Structure of the Soil Bacterium Myxococcus xanthus at the Centimeter Scale. Appl. Envir. Microbiol., May 1, 2006; 72(5): 3615 - 3625. [Abstract] [Full Text] [PDF]

				M. Yawata, N. Yawata, M. Draghi, A.-M. Little, F. Partheniou, and P. Parham Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function J. Exp. Med., March 20, 2006; 203(3): 633 - 645. [Abstract] [Full Text] [PDF]

				S. C. Gonzalez-Martinez, E. Ersoz, G. R. Brown, N. C. Wheeler, and D. B. Neale DNA Sequence Variation and Selection of Tag Single-Nucleotide Polymorphisms at Candidate Genes for Drought-Stress Response in Pinus taeda L. Genetics, March 1, 2006; 172(3): 1915 - 1926. [Abstract] [Full Text] [PDF]

				H. Innan, K. Zhang, P. Marjoram, S. Tavare, and N. A. Rosenberg Statistical Tests of the Coalescent Model Based on the Haplotype Frequency Distribution and the Number of Segregating Sites Genetics, March 1, 2005; 169(3): 1763 - 1777. [Abstract] [Full Text] [PDF]

				Y. Vigouroux, S. Mitchell, Y. Matsuoka, M. Hamblin, S. Kresovich, J. S. C. Smith, J. Jaqueth, O. S. Smith, and J. Doebley An Analysis of Genetic Diversity Across the Maize Genome Using Microsatellites Genetics, March 1, 2005; 169(3): 1617 - 1630. [Abstract] [Full Text] [PDF]

				Y. Vigouroux, M. McMullen, C. T. Hittinger, K. Houchins, L. Schulz, S. Kresovich, Y. Matsuoka, and J. Doebley Identifying genes of agronomic importance in maize by screening microsatellites for evidence of selection during domestication PNAS, July 23, 2002; 99(15): 9650 - 9655. [Abstract] [Full Text] [PDF]

				J. Tang, S. Tang, E. Lobashevsky, A. D. Myracle, U. Fideli, G. Aldrovandi, S. Allen, R. Musonda, and R. A. Kaslow Favorable and Unfavorable HLA Class I Alleles and Haplotypes in Zambians Predominantly Infected with Clade C Human Immunodeficiency Virus Type 1 J. Virol., July 19, 2002; 76(16): 8276 - 8284. [Abstract] [Full Text] [PDF]

				B. A. Payseur, A. D. Cutter, and M. W. Nachman Searching for Evidence of Positive Selection in the Human Genome Using Patterns of Microsatellite Variability Mol. Biol. Evol., July 1, 2002; 19(7): 1143 - 1153. [Abstract] [Full Text] [PDF]

				W.-G. Qiu, D. E. Dykhuizen, M. S. Acosta, and B. J. Luft Geographic Uniformity of the Lyme Disease Spirochete (Borrelia burgdorferi) and Its Shared History With Tick Vector (Ixodes scapularis) in the Northeastern United States Genetics, March 1, 2002; 160(3): 833 - 849. [Abstract] [Full Text] [PDF]

				S. W. Schaeffer, C. S. Walthour, D. M. Toleno, A. T. Olek, and E. L. Miller Protein Variation in ADH and ADH-RELATED in Drosophila pseudoobscura: Linkage Disequilibrium Between Single Nucleotide Polymorphisms and Protein Alleles Genetics, October 1, 2001; 159(2): 673 - 687. [Abstract] [Full Text] [PDF]

				P. Donnelly, M. Nordborg, and P. Joyce Likelihoods and Simulation Methods for a Class of Nonneutral Population Genetics Models Genetics, October 1, 2001; 159(2): 853 - 867. [Abstract] [Full Text] [PDF]

				M. J. Donnelly, M. C. Licht, and T. Lehmann Evidence for Recent Population Expansion in the Evolutionary History of the Malaria Vectors Anopheles arabiensis and Anopheles gambiae Mol. Biol. Evol., July 1, 2001; 18(7): 1353 - 1364. [Abstract] [Full Text] [PDF]

				J. A. Labate Software for Population Genetic Analyses of Molecular Marker Data Crop Sci., November 1, 2000; 40(6): 1521 - 1528. [Abstract] [Full Text] [PDF]

				M. H. Kohn, H.-J. Pelz, and R. K. Wayne Natural selection mapping of the warfarin-resistance gene PNAS, July 5, 2000; 97(14): 7911 - 7915. [Abstract] [Full Text] [PDF]

				J. Jaruzelska, E. Zietkiewicz, M. Batzer, D. E. C. Cole, J.-P. Moisan, R. Scozzari, S. Tavaré, and D. Labuda Spatial and Temporal Distribution of the Neutral Polymorphisms in the Last ZFX Intron: Analysis of the Haplotype Structure and Genealogy Genetics, July 1, 1999; 152(3): 1091 - 1101. [Abstract] [Full Text]

				H. Salamon, W. Klitz, S. Easteal, X. Gao, H. A. Erlich, M. Fernandez-Viña, E. A. Trachtenberg, S. K. McWeeney, M. P. Nelson, and G. Thomson Evolution of HLA Class II Molecules: Allelic and Amino Acid Site Variability Across Populations Genetics, May 1, 1999; 152(1): 393 - 400. [Abstract] [Full Text]

				H. Akashi Inferring the Fitness Effects of DNA Mutations From Polymorphism and Divergence Data: Statistical Power to Detect Directional Selection Under Stationarity and Free Recombination Genetics, January 1, 1999; 151(1): 221 - 238. [Abstract] [Full Text]

				Departure from Neutrality at the Mitochondrial NADH Dehydrogenase Subunit 2 Gene in Humans, but Not in Chimpanzees Genetics, January 1, 1998; 148(1): 409 - 422.