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- Articles by Lusis, A. J.
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X-LINKED AND AUTOSOMAL GENES CONTROLLING MOUSE 
-GALACTOSIDASE
EXPRESSION
Aldons J. Lusis 1 and John D. West 1
1 Molecular Biology Department, Roswell Park Memorial Institute,
666 Elm Street, Buffalo, New York 14263
Analysis of F2 and backcross animals has confirmed
the X-chromosome linkage of Ags, the structural locus for
mouse 
-galactosidase. The position of Ags has been located
in the X chromosome, 9 centimorgans from Mo, and the gene
order is centromere-Hq-Bn-Ta-Mo-Ags. A variation in the developmental
expression of -galactosidase activity, inherited as an autosomal trait,
has been characterized using recombinant inbred lines of mice. Among certain
recombinant inbred lines, the variation appears to segregate as a single major
locus.
Revised on October 25, 1977