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THE GENETICS OF 
-HYDROXYACID OXIDASE AND ALCOHOL DEHYDROGENASE
IN THE MOUSE: EVIDENCE FOR MULTIPLE GENE LOCI AND LINKAGE BETWEEN Hao-2
AND Adh-3
Roger S. Holmes 1
1 School of Science, Griffith University, Nathan, 4111, Queensland,
Australia
Electrophoretic polymorphisms for stomach alcohol dehydrogenase
(ADH-C2) and kidney L-
-hydroxyacid oxidase (HAOX-B
4) have been identified in an Asian subspecies of mouse, Mus musculus
castaneous. These variants are inherited in a normal Mendelian fashion
with two alleles in each case showing codominant expression. The structural
gene loci for those enzymes (Adh-3 and Hao-2, respectively)
are apparently linked (17.6% recombinants) in this organism, whereas the multiple
gene loci for HAOX, Hao-1 (encoding the A4 liver isozyme)
and Hao-2, exhibited independent segregation and are unlinked (50%
recombinants). Evidence is presented for 3 ADH loci: Adh-1, encoding
liver ADH-A2 which exhibits high activity with ethanol (Selander,
Hunt and Yang 1969; Adh-2, liver and stomach ADH-B
2 using 2-hexene-1-ol as substrate; and Adh-3, stomach ADH-C
2 using both benzyl alcohol and 2-hexene-1-ol as substrate.
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