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A COMPARISON OF SURVIVAL AND REPAIR OF UV-INDUCED DNA DAMAGE IN CULTURED INSECT VERSUS MAMMALIAN CELLS
Thomas M. Koval 1, Ronald W. Hart 2, Willard C. Myser 1, and Walter F. Hink 3
1 Department of Zoology, The Ohio State University, Columbus,
Ohio
2 Department of Radiology, The Ohio State University, Columbus,
Ohio
3 Department of Entomology, The Ohio State University, Columbus,
Ohio
Survival and unscheduled DNA synthesis (UDS) were measured in a cultured insect cell line, TN-368, and a cultured mammalian cell line, V-79-4, following exposure to several fluences of ultraviolet light. TN-368 cells were approximately seven times more resistant to the lethal effects of UV than V-79 cells, as determined by colony formation. The amount of UDS per unit amount of DNA is about the same in both cell types 4 hr after 10–50 J/m2 UV irradiations.
Submitted on April 12, 1977