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ELECTROPHORETIC VARIATION FOR X-CHROMOSOME-LINKED PHOSPHOGLYCERATE KINASE (PGK-1) IN THE MOUSE
J. T. Nielsen 1 and V. M. Chapman 2
1 Institute of Genetics, University of Aarhus, Aarhus, Denmark
2 Department of Molecular Biology, Roswell Park Memorial Institute,
Buffalo, New York
Electrophoretic variation for X-chromosome-linked phosphoglycerate kinase (PGK-1) has been found as a polymorphism in feral mice in Denmark. Males from feral sampling or from a variety of genetic crosses have only a single-banded phenotype of the variant PGK-1A type or of the PGK-1B type commonly found among inbred mice. By contrast, three phenotypes were observed among females; two homozygous single-banded types and a heterozygous double-banded type. The X-chromosome linkage of the Pgk-1 locus was determined from the mode of inheritance in F1 and backcross generations and confirmed by the linkage of Pgk-1 and the X-linked markers Hq, Ta and Mo. Pgk-1 showed 29/122 recombinations with Hq, 5/185 with Ta and 0/108 recombinants with Mo. Based on these recombination data, a gene order of Hq—Ta—Pgk-1—Mo is suggested.
Submitted on February 10, 1977Revised on July 5, 1977
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