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INCREASED SPONTANEOUS MITOTIC SEGREGATION IN MMS-SENSITIVE MUTANTS OF SACCHAROMYCES CEREVISIAE
Satya Prakash 1 and Louise Prakash 2
1 Department of Biology, University of Rochester, Rochester,
New York 14627
2 Department of Radiation Biology and Biophysics, University
of Rochester School of Medicine and Dentistry, Rochester, New York 14642
Methyl methanesulfonate (MMS)-sensitive mutants of Saccharomyces cerevisiae belonging to four different complementation groups, when homozygous, increase the rate of spontaneous mitotic segregation to canavanine resistance from heterozygous sensitive (canr/+) diploids by 13- to 170-fold. The mms8–1 mutant is MMS and X-ray sensitive and increases the rate of spontaneous mitotic segregation 170-fold. The mms9–1 and mms13–1 mutants are sensitive to X rays and UV, respectively, in addition to MMS, and increase the rate of spontaneous mitotic segregation by 13-fold and 85-fold, respectively. The mutant mms21–1 is sensitive to MMS, X rays and UV and increases the rate of spontaneous mitotic segregation 23-fold.
Submitted on August 6, 1976Revised on June 23, 1977
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