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THREE LINKED ENZYME LOCI IN FISHES: IMPLICATIONS IN THE EVOLUTION OF VERTEBRATE CHROMOSOMES
Donald C. Morizot 1, David A. Wright 1, and Michael J. Siciliano 1
1 University of Texas Graduate School of Biomedical Sciences
and System Cancer Center, Houston, Texas 77030
A three-point linkage group comprised of loci coding for adenosine
deaminase (ADA), glucose-6-phosphate dehydrogenase (G6PDH), and 6-phosphogluconate
dehydrogenase (6PGD) is described in fish of the genus Xiphophorus (Poeciliidae).
The alleles at loci in this group were shown to assort independently from
the alleles at three other loci—isocitrate dehydrogenase 1 and
2, and glyceraldehyde-3-phosphate dehydrogenase 1. Alleles at
the latter three loci also assort independently from each other. Data were
obtained by observing the segregation of electrophoretically variant alleles
in reciprocal backcross hybrids derived from crosses between either X.
helleri guentheri or X. h. strigatus and X. maculatus.
The linkage component of 
2 was significant (<0.01) in all
crosses, indicating that the linkage group is conserved in all populations
of both species of Xiphophorus examined. While data from X. h. guentheri
backcrosses indicate the linkage relationship ADA—6%—
G6PDH—24%—6PGD, and ADA—29%—
6PGD (30% when corrected for double cross-overs), data from backcrosses
involving strigatus, while supporting the same gene order, yielded
significantly different recombination frequencies. The likelihood of the difference
being due to an inversion could not be separated from the possibility of a
sex effect on recombination in the present data. The linkage of 6PGD and G6PDH
has been shown to exist in species of at least three classes of vertebrates,
indicating the possibility of evolutionary conservation of this linkage.
Revised on March 17, 1977
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