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INTERCONVERSION OF YEAST MATING TYPES III. ACTION OF THE HOMOTHALLISM (HO) GENE IN CELLS HOMOZYGOUS FOR THE MATING TYPE LOCUS
James B. Hicks 1, Jeffrey N. Strathern 1, and Ira Herskowitz 1
1 Institute of Molecular Biology and Department of Biology,
University of Oregon, Eugene, Oregon 97403
Mating type interconversion in homothallic Saccharomyces
cerevisiae has been studied in diploids homozygous for the mating type
locus produced by sporulation of a/a/a/
and
a/a// tetraploid strains. Mating type switches have
been analyzed by techniques including direct observation of cells for changes
in -factor sensitivity. Another method of following mating type switching
exploits the observation that a/ cells exhibit polar budding
and a/a and / cells exhibit medial budding.—These
studies indicate the following: (1) The allele conferring the homothallic
life cycle (HO) is dominant to the allele conferring the heterothallic life
cycle (ho). (2) The action of the HO gene is controlled
by the mating type locus—active in a/a and /
cells but not in a/ cells. (3) The HO (or HO-controlled)
gene product can act independently on two mating type alleles located on separate
chromosomes in the same nucleus. (4) A switch in mating type is observed in
pairs of cells, each of which has the same change.
Revised on December 10, 1976
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