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ON THE NATURE OF CIS-ACTING REGULATORY PROTEINS AND
GENETIC ORGANIZATION IN BACTERIOPHAGE: THE EXAMPLE OF GENE Q OF BACTERIOPHAGE 
Harrison Echols 1, Donald Court 2, and Linda Green 1
1 Department of Molecular Biology, University of California,
Berkeley, California 94720
2 Laboratory of Molecular Biology, National Cancer Institute,
Bethesda, Maryland 20014
We note the existence of a "partially cis-acting" regulatory
protein of bacteriophage 
: the product of the phage Q gene.
We suggest that there may be a complete spectrum from "all cis" to
"all trans" for such regulatory proteins. This behavior might arise
because a DNA-binding protein either acts at a nearby (cis) site
soon after synthesis or becomes "lost" for its trans activity on
another genome through nonspecific interactions with DNA. Our proposed explanation
provides one evolutionary basis for the linkage of genes for regulatory proteins
and the sites at which such proteins act; it also suggests a possible rationale
for the "metabolic instability" of certain regulatory proteins.
Revised on January 15, 1976
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