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TERMINAL REDUNDANCY HETEROZYGOTES INVOLVING THE FIRST-STEP-TRANSFER REGION OF THE BACTERIOPHAGE T5 CHROMOSOME
David Fischhoff 1, Douglas MacNeil 1, and Nancy Kleckner 1
1 Department of Biology, Massachusetts Institute of Technology,
Cambridge, Massachusetts 02139
Individual progeny of two-factor crosses between A1am and A2am T5 phages give rise to bursts containing more than one type of plaque. The simplest explanation for these mixed bursts is that the A1 and A2 genes are located within the terminally repeated portion of the T5 genome and that the mixed bursts are made by "terminal redundancy heterozygotes". The observation of genetic heterozygosity means that the A1 and A2 genes are repeated intact. This implies that the terminal segments of T5 are genetically interchangeable.
Submitted on July 30, 1975