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MATING TYPE AND SPORULATION IN YEAST I. MUTATIONS WHICH ALTER MATING-TYPE CONTROL OVER SPORULATION
Anita K. Hopper 1 and Benjamin D. Hall 1
1 Department of Genetics, University of Washington, Seattle,
Washington 98195
In Saccharomyces cerevisiae, meiosis and spore formation
as well as mating are controlled by mating-type genes. Diploids heterozygous
for mating type (a
) can sporulate but cannot mate; homozygous
aa and diploids can mate, but cannot sporulate. From an
diploid parental strain, we have isolated mutants which have gained the ability
to sporulate. Those mutants which continue to mate as cells
have been designated CSP (control of sporulation). Upon sporulation,
CSP mutants yield asci containing 4 spores. The mutant gene which
allows cells to sporulate is unlinked to the mating-type locus
and also acts to permit sporulation in aa diploid cells. Segregation
data from crosses between mutant and wild-type aa diploids
and vice versa indicate (for all but one mutant) that the mutation
which allows constitutive sporulation (CSP) is dominant over the
wild-type allele. Some of the CSP mutants are temperature-sensitive,
sporulating at 32°, but not at 23°. In addition to CSP mutants,
our mutagenesis and screening procedure led to the isolation of mutants which
sporulate by virtue of a change in the mating-type locus itself, resulting
in loss of ability to mate.
Revised on November 22, 1974
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