- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Bewley, G. C.
- Articles by Lucchesi, J. C.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Bewley, G. C.
- Articles by Lucchesi, J. C.
LETHAL EFFECTS OF LOW AND "NULL" ACTIVITY ALLELES OF 6-PHOSPHOGLUCONATE DEHYDROGENASE IN DROSOPHILA MELANOGASTER
Glenn C. Bewley 1 and John C. Lucchesi 2
1 Department of Zoology, University of North Carolina, Chapel Hill, North Carolina 27514
2 Curriculum in Genetics, University of North Carolina, Chapel Hill, North Carolina 27514
EMS-induced "null" and low activity alleles for 6-phosphogluconate dehydrogenase were characterized with respect to enzymatic activity, relative viability, fertility, and the effective lethal phase. It was determined that flies hemizygous and homozygous for the low activity allele, Pgd-, possessed a depressed developmental rate, diminished viability, and loss of female fertility. Heterozygotes for Pgd- and a deficiency for Pgd+ were lethal. The "null" activity allele demonstrated a lethal phenotype in both the hemizygous and homozygous condition. The effective lethal phase for the "null" allele occurs during late embryonic development (20–22 hr).
Submitted on July 19, 1974
This article has been cited by other articles:
 |
|
 |
|
  M. Hughes and J. Lucchesi Genetic rescue of a lethal "null" activity allele of 6-phosphogluconate dehydrogenase in Drosophila melanogaster Science, June 3, 1977; 196(4294): 1114 - 1115. [Abstract] [PDF]
|
|