- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Littlewood, B. S.
- Articles by Metzenberg, R. L.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Littlewood, B. S.
- Articles by Metzenberg, R. L.
GENETIC CONTROL OF PHOSPHATE-METABOLIZING ENZYMES IN NEUROSPORA CRASSA: RELATIONSHIPS AMONG REGULATORY MUTATIONS
Barbara S. Littlewood 1, William Chia 1, and Robert L. Metzenberg 1
1 Department of Physiological Chemistry, University of Wisconsin, Madison, Wisconsin 53706
In Neurospora crassa, the phosphate-metabolizing enzymes are made during phosphate starvation, but not under phosphate sufficiency. The synthesis of these enzymes is controlled by three regulatory genes: pcon-nuc-2, preg and nuc-1. pcon-nuc-2 and preg are closely linked. A model of the hierarchical relationships among these regulatory genes is presented. Studies of double mutants and revertants confirm several predictions of the model. It has been found that nuc-2 (null) and pconc (constitutive) mutations reside in the same cistron. pregc (constitutive) mutations are epistatic to nuc-2 mutations. nuc-1 (null) mutations are epistatic to all others.
Submitted on September 12, 1974
This article has been cited by other articles:
 |
|
 |
|
  J.-L. Battini, J. E. J. Rasko, and A. D. Miller A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: Possible role in G protein-coupled signal transduction PNAS, February 16, 1999; 96(4): 1385 - 1390. [Abstract] [Full Text] [PDF]
|
|