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DOSAGE COMPENSATION OF GENES ON THE LEFT AND RIGHT ARMS OF THE X CHROMOSOME OF DROSOPHILA PSEUDOOBSCURA AND DROSOPHILA WILLISTONI
Irene Abraham 1 and John C. Lucchesi 2
1 Department of Zoology, University of North Carolina, Chapel Hill, North Carolina 27514
2 Curriculum in Genetics, University of North Carolina, Chapel Hill, North Carolina 27514
We have investigated the occurrence of dosage compensation in D. willistoni and D. pseudoobscura, two species whose X chromosome is metacentric with one arm homologous to the X and the other homologous to the left arm of chromosome 3 of D. melanogaster. Crude extracts were assayed for isocitrate dehydrogenase (XR), glucose-6-phosphate dehydrogenase (XL?), 6-phosphogluconate dehydrogenase (XL?), and 
-glycerophosphate dehydrogenase (chromosome 2) in D. willistoni, and for esterase-5 (XR), glucose-6-phosphate dehydrogenase (XL?), 6-phosphogluconate dehydrogenase (XL?) and amylase (chromosome 3) in D. pseudoobscura. Our results indicate that a mechanism for dosage compensation is operative in both arms of the X chromosome of these two species.
Revised on July 22, 1974
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  J. Lucchesi Gene dosage compensation and the evolution of sex chromosomes Science, November 17, 1978; 202(4369): 711 - 716. [Abstract] [PDF]
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