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THE BACILLUS SUBTILIS GENOME: REPLICATION-ORDER AND MAP-POSITION DISCREPANCIES—EVIDENCE FOR A SECOND ORIGIN
James C. Copeland 1
1 Department of Microbiology, College of Biological Sciences, Ohio State University, 484 West 12th Avenue, Columbus, Ohio 43210
Replication order to map position discrepancies have been documented in B. subtilis. The discrepancies were found to occur whenever the genome of B. subtilis was replicated under a variety of physiological conditions and in both 168 and W23 strains. The earliest replicating marker involved in these discrepancies was thr versus purB and aroA versus recA. A detailed linkage analysis of the ura to argA region was consistent with its being a continuous linkage group. This led to the conclusion that an origin for new starts at replication exists between recA and aroA.
Submitted on March 11, 1974Revised on July 12, 1974