- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Gatti, M.
- Articles by Olivieri, G.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Gatti, M.
- Articles by Olivieri, G.
ANALYSIS OF THE CHROMOSOME ABERRATIONS INDUCED BY X-RAYS IN SOMATIC CELLS OF DROSOPHILA MELANOGASTER
M. Gatti 1, C. Tanzarella 1, and G. Olivieri 1
1 Istituto di Genetica, Facoltà di Scienze, Università di Roma, Rome, Italy
A technique has been perfected for enabling good microscope preparations to be obtained from the larval ganglia of Drosophila melanogaster. This system was then tested with X-rays and an extensive series of data was obtained on the chromosome aberrations induced in the various stages of the cell cycle.—The analysis of the results obtained offers the following points of interest: (1) There exists a difference in radio-sensitivity between the two sexes. The females constantly display a greater frequency of both chromosome and chromatid aberrations. They also display a greater frequency of spontaneous aberrations. (2) In both sexes the overall chromosome damage is greater in cells irradiated in stages G2 and G1. These two peaks of greater radiosensitivity are produced by a high frequency of terminal deletions and chromatid exchanges and by a high frequency of dicentrics, respectively. (3) The aberrations are not distributed at random among the various chromosomes. On the average, the Y chromosome is found to be more resistant and the breaks are preferentially localized in the pericentromeric heterochromatin of the X chromosome and of the autosomes. (4) Somatic pairing influences the frequency and type of the chromosome aberrations induced. In this system, such an arrangement of the chromosomes results in a high frequency of exchanges and dicentrics between homologous chromosomes and a low frequency of scorable translocations. Moreover, somatic pairing, probably by preventing the formation of looped regions in the interphase chromosomes, results in the almost total absence of intrachanges at both chromosome and chromatid level.
Submitted on February 28, 1974
This article has been cited by other articles:
 |
|
 |
|
  A. M. Bentley, B. C. Williams, M. L. Goldberg, and A. J. Andres Phenotypic characterization of Drosophila ida mutants: defining the role of APC5 in cell cycle progression J. Cell Sci., January 3, 2002; 115(5): 949 - 961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Csink and S. Henikoff Large-scale Chromosomal Movements During Interphase Progression in Drosophila J. Cell Biol., October 5, 1998; 143(1): 13 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Beumer, S. Pimpinelli, and K. G. Golic Induced Chromosomal Exchange Directs the Segregation of Recombinant Chromatids in Mitosis of Drosophila Genetics, September 1, 1998; 150(1): 173 - 188. [Full Text]
|
|
|
|
 |
|
 D. Castrillon and S. Wasserman Diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene Development, January 12, 1994; 120(12): 3367 - 3377. [Abstract] [PDF]
|
|
|
|
 |
|
 M Gatti and B S Baker Genes controlling essential cell-cycle functions in Drosophila melanogaster. Genes & Dev., April 1, 1989; 3(4): 438 - 453. [Abstract] [PDF]
|
|
|
|
 |
|
 M Gatti, D. Smith, and B. Baker A gene controlling condensation of heterochromatin in Drosophila melanogaster Science, July 1, 1983; 221(4605): 83 - 85. [Abstract] [PDF]
|
|