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SELECTION FOR HIGH MUTATION RATES IN CHEMOSTATS
Edward C. Cox 1 and Thomas C. Gibson 1
1 Department of Biology, Princeton University, Princeton, N.J. 08540
Competition experiments in chemostats show that mutator populations of Escherichia coli are more fit than wild type. The increased fitness can be explained by the appearance of new mutants better adapted to the chemostat environment. Fitness values vary between chemostats and are strongly correlated (P < 0.001) with fluctuations in population density.
Submitted on October 15, 1973Revised on February 9, 1974
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