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THE GENETICS OF CAENORHABDITIS ELEGANS
S. Brenner 1
1 Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, England
Methods are described for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm. About 300 EMS-induced mutants affecting behavior and morphology have been characterized and about one hundred genes have been defined. Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large.
Submitted on December 10, 1973
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N. Takata, B. Itoh, K. Misaki, T. Hirose, S. Yonemura, and M. Okada Non-receptor tyrosine kinase CSK-1 controls pharyngeal muscle organization in Caenorhabditis elegans Genes Cells, March 1, 2009; 14(3): 381 - 393. [Abstract] [Full Text] [PDF]
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X. Han, J.-E. Gomes, C. L. Birmingham, L. Pintard, A. Sugimoto, and P. E. Mains The Role of Protein Phosphatase 4 in Regulating Microtubule Severing in the Caenorhabditis elegans Embryo Genetics, March 1, 2009; 181(3): 933 - 943. [Abstract] [Full Text] [PDF]
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J. R. Powell, D. H. Kim, and F. M. Ausubel The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response PNAS, February 24, 2009; 106(8): 2782 - 2787. [Abstract] [Full Text] [PDF]
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B. R. Daniels, E. M. Perkins, T. M. Dobrowsky, S. X. Sun, and D. Wirtz Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusion J. Cell Biol., February 23, 2009; 184(4): 473 - 479. [Abstract] [Full Text] [PDF]
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A. M. Jose, J. J. Smith, and C. P. Hunter Export of RNA silencing from C. elegans tissues does not require the RNA channel SID-1 PNAS, February 17, 2009; 106(7): 2283 - 2288. [Abstract] [Full Text] [PDF]
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H. Wang, P. J. Lim, M. Karbowski, and M. J. Monteiro Effects of overexpression of Huntingtin proteins on mitochondrial integrity Hum. Mol. Genet., February 15, 2009; 18(4): 737 - 752. [Abstract] [Full Text] [PDF]
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K. L. Schmidt, N. Marcus-Gueret, A. Adeleye, J. Webber, D. Baillie, and E. G. Stringham The cell migration molecule UNC-53/NAV2 is linked to the ARP2/3 complex by ABI-1 Development, February 15, 2009; 136(4): 563 - 574. [Abstract] [Full Text] [PDF]
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T. R. Jones, A. E. Carpenter, M. R. Lamprecht, J. Moffat, S. J. Silver, J. K. Grenier, A. B. Castoreno, U. S. Eggert, D. E. Root, P. Golland, et al. Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning PNAS, February 10, 2009; 106(6): 1826 - 1831. [Abstract] [Full Text] [PDF]
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G. P. Harris, V. M. Hapiak, R. T. Wragg, S. B. Miller, L. J. Hughes, R. J. Hobson, R. Steven, B. Bamber, and R. W. Komuniecki Three Distinct Amine Receptors Operating at Different Levels within the Locomotory Circuit Are Each Essential for the Serotonergic Modulation of Chemosensation in Caenorhabditis elegans J. Neurosci., February 4, 2009; 29(5): 1446 - 1456. [Abstract] [Full Text] [PDF]
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A. Tong, G. Lynn, V. Ngo, D. Wong, S. L. Moseley, J. J. Ewbank, A. Goncharov, Y.-C. Wu, N. Pujol, and A. D. Chisholm Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase PNAS, February 3, 2009; 106(5): 1457 - 1461. [Abstract] [Full Text] [PDF]
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S. Chen, J. R. Whetstine, S. Ghosh, J. A. Hanover, R. R. Gali, P. Grosu, and Y. Shi The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span PNAS, February 3, 2009; 106(5): 1496 - 1501. [Abstract] [Full Text] [PDF]
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B. J. Lesch, A. R. Gehrke, M. L. Bulyk, and C. I. Bargmann Transcriptional regulation and stabilization of left-right neuronal identity in C. elegans Genes & Dev., February 1, 2009; 23(3): 345 - 358. [Abstract] [Full Text] [PDF]
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J. Luo, S. Shah, K. Riabowol, and P. E. Mains The Caenorhabditis elegans ing-3 Gene Regulates Ionizing Radiation-Induced Germ-Cell Apoptosis in a p53-Associated Pathway Genetics, February 1, 2009; 181(2): 473 - 482. [Abstract] [Full Text] [PDF]
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M. E. Mabon, X. Mao, Y. Jiao, B. A. Scott, and C. M. Crowder Systematic Identification of Gene Activities Promoting Hypoxic Death Genetics, February 1, 2009; 181(2): 483 - 496. [Abstract] [Full Text] [PDF]
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B. J. Kemp, D. L. Church, J. Hatzold, B. Conradt, and E. J. Lambie gem-1 Encodes an SLC16 Monocarboxylate Transporter-Related Protein That Functions in Parallel to the gon-2 TRPM Channel During Gonad Development in Caenorhabditis elegans Genetics, February 1, 2009; 181(2): 581 - 591. [Abstract] [Full Text] [PDF]
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G.-d. Zhu, G. Salazar, S. A. Zlatic, B. Fiza, M. M. Doucette, C. J. Heilman, A. I. Levey, V. Faundez, and S. W. L'Hernault SPE-39 Family Proteins Interact with the HOPS Complex and Function in Lysosomal Delivery Mol. Biol. Cell, February 1, 2009; 20(4): 1223 - 1240. [Abstract] [Full Text] [PDF]
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K. Sato, G. G. Ernstrom, S. Watanabe, R. M. Weimer, C.-H. Chen, M. Sato, A. Siddiqui, E. M. Jorgensen, and B. D. Grant Differential requirements for clathrin in receptor-mediated endocytosis and maintenance of synaptic vesicle pools PNAS, January 27, 2009; 106(4): 1139 - 1144. [Abstract] [Full Text] [PDF]
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 T. C. Sudhof and J. E. Rothman Membrane Fusion: Grappling with SNARE and SM Proteins Science, January 23, 2009; 323(5913): 474 - 477. [Abstract] [Full Text] [PDF]
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Y.-Y. Hsiao, A. Nakagawa, Z. Shi, S. Mitani, D. Xue, and H. S. Yuan Crystal Structure of CRN-4: Implications for Domain Function in Apoptotic DNA Degradation Mol. Cell. Biol., January 15, 2009; 29(2): 448 - 457. [Abstract] [Full Text] [PDF]
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M. Briese, B. Esmaeili, S. Fraboulet, E. C. Burt, S. Christodoulou, P. R. Towers, K. E. Davies, and D. B. Sattelle Deletion of smn-1, the Caenorhabditis elegans ortholog of the spinal muscular atrophy gene, results in locomotor dysfunction and reduced lifespan Hum. Mol. Genet., January 1, 2009; 18(1): 97 - 104. [Abstract] [Full Text] [PDF]
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C. Kang and L. Avery Systemic regulation of starvation response in Caenorhabditis elegans Genes & Dev., January 1, 2009; 23(1): 12 - 17. [Abstract] [Full Text] [PDF]
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V. M. Hapiak, R. J. Hobson, L. Hughes, K. Smith, G. Harris, C. Condon, P. Komuniecki, and R. W. Komuniecki Dual Excitatory and Inhibitory Serotonergic Inputs Modulate Egg Laying in Caenorhabditis elegans Genetics, January 1, 2009; 181(1): 153 - 163. [Abstract] [Full Text] [PDF]
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