THE GENETICS OF CAENORHABDITIS ELEGANS

1 Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, England

Methods are described for the isolation, complementation and mapping of mutants of Caenorhabditis elegans, a small free-living nematode worm. About 300 EMS-induced mutants affecting behavior and morphology have been characterized and about one hundred genes have been defined. Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large.

Submitted on December 10, 1973




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Genes Cells, March 1, 2009; 14(3): 381 - 393.
[Abstract] [Full Text] [PDF]


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GeneticsHome page
X. Han, J.-E. Gomes, C. L. Birmingham, L. Pintard, A. Sugimoto, and P. E. Mains
The Role of Protein Phosphatase 4 in Regulating Microtubule Severing in the Caenorhabditis elegans Embryo
Genetics, March 1, 2009; 181(3): 933 - 943.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
J. R. Powell, D. H. Kim, and F. M. Ausubel
The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response
PNAS, February 24, 2009; 106(8): 2782 - 2787.
[Abstract] [Full Text] [PDF]


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JCBHome page
B. R. Daniels, E. M. Perkins, T. M. Dobrowsky, S. X. Sun, and D. Wirtz
Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusion
J. Cell Biol., February 23, 2009; 184(4): 473 - 479.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
A. M. Jose, J. J. Smith, and C. P. Hunter
Export of RNA silencing from C. elegans tissues does not require the RNA channel SID-1
PNAS, February 17, 2009; 106(7): 2283 - 2288.
[Abstract] [Full Text] [PDF]


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Hum Mol GenetHome page
H. Wang, P. J. Lim, M. Karbowski, and M. J. Monteiro
Effects of overexpression of Huntingtin proteins on mitochondrial integrity
Hum. Mol. Genet., February 15, 2009; 18(4): 737 - 752.
[Abstract] [Full Text] [PDF]


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DevelopmentHome page
K. L. Schmidt, N. Marcus-Gueret, A. Adeleye, J. Webber, D. Baillie, and E. G. Stringham
The cell migration molecule UNC-53/NAV2 is linked to the ARP2/3 complex by ABI-1
Development, February 15, 2009; 136(4): 563 - 574.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
T. R. Jones, A. E. Carpenter, M. R. Lamprecht, J. Moffat, S. J. Silver, J. K. Grenier, A. B. Castoreno, U. S. Eggert, D. E. Root, P. Golland, et al.
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning
PNAS, February 10, 2009; 106(6): 1826 - 1831.
[Abstract] [Full Text] [PDF]


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J. Neurosci.Home page
G. P. Harris, V. M. Hapiak, R. T. Wragg, S. B. Miller, L. J. Hughes, R. J. Hobson, R. Steven, B. Bamber, and R. W. Komuniecki
Three Distinct Amine Receptors Operating at Different Levels within the Locomotory Circuit Are Each Essential for the Serotonergic Modulation of Chemosensation in Caenorhabditis elegans
J. Neurosci., February 4, 2009; 29(5): 1446 - 1456.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
A. Tong, G. Lynn, V. Ngo, D. Wong, S. L. Moseley, J. J. Ewbank, A. Goncharov, Y.-C. Wu, N. Pujol, and A. D. Chisholm
Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase
PNAS, February 3, 2009; 106(5): 1457 - 1461.
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Proc. Natl. Acad. Sci. USAHome page
S. Chen, J. R. Whetstine, S. Ghosh, J. A. Hanover, R. R. Gali, P. Grosu, and Y. Shi
The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span
PNAS, February 3, 2009; 106(5): 1496 - 1501.
[Abstract] [Full Text] [PDF]


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Genes Dev.Home page
B. J. Lesch, A. R. Gehrke, M. L. Bulyk, and C. I. Bargmann
Transcriptional regulation and stabilization of left-right neuronal identity in C. elegans
Genes & Dev., February 1, 2009; 23(3): 345 - 358.
[Abstract] [Full Text] [PDF]


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GeneticsHome page
J. Luo, S. Shah, K. Riabowol, and P. E. Mains
The Caenorhabditis elegans ing-3 Gene Regulates Ionizing Radiation-Induced Germ-Cell Apoptosis in a p53-Associated Pathway
Genetics, February 1, 2009; 181(2): 473 - 482.
[Abstract] [Full Text] [PDF]


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GeneticsHome page
M. E. Mabon, X. Mao, Y. Jiao, B. A. Scott, and C. M. Crowder
Systematic Identification of Gene Activities Promoting Hypoxic Death
Genetics, February 1, 2009; 181(2): 483 - 496.
[Abstract] [Full Text] [PDF]


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GeneticsHome page
B. J. Kemp, D. L. Church, J. Hatzold, B. Conradt, and E. J. Lambie
gem-1 Encodes an SLC16 Monocarboxylate Transporter-Related Protein That Functions in Parallel to the gon-2 TRPM Channel During Gonad Development in Caenorhabditis elegans
Genetics, February 1, 2009; 181(2): 581 - 591.
[Abstract] [Full Text] [PDF]


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Mol. Biol. CellHome page
G.-d. Zhu, G. Salazar, S. A. Zlatic, B. Fiza, M. M. Doucette, C. J. Heilman, A. I. Levey, V. Faundez, and S. W. L'Hernault
SPE-39 Family Proteins Interact with the HOPS Complex and Function in Lysosomal Delivery
Mol. Biol. Cell, February 1, 2009; 20(4): 1223 - 1240.
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Proc. Natl. Acad. Sci. USAHome page
K. Sato, G. G. Ernstrom, S. Watanabe, R. M. Weimer, C.-H. Chen, M. Sato, A. Siddiqui, E. M. Jorgensen, and B. D. Grant
Differential requirements for clathrin in receptor-mediated endocytosis and maintenance of synaptic vesicle pools
PNAS, January 27, 2009; 106(4): 1139 - 1144.
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ScienceHome page
T. C. Sudhof and J. E. Rothman
Membrane Fusion: Grappling with SNARE and SM Proteins
Science, January 23, 2009; 323(5913): 474 - 477.
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Mol. Cell. Biol.Home page
Y.-Y. Hsiao, A. Nakagawa, Z. Shi, S. Mitani, D. Xue, and H. S. Yuan
Crystal Structure of CRN-4: Implications for Domain Function in Apoptotic DNA Degradation
Mol. Cell. Biol., January 15, 2009; 29(2): 448 - 457.
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Hum Mol GenetHome page
M. Briese, B. Esmaeili, S. Fraboulet, E. C. Burt, S. Christodoulou, P. R. Towers, K. E. Davies, and D. B. Sattelle
Deletion of smn-1, the Caenorhabditis elegans ortholog of the spinal muscular atrophy gene, results in locomotor dysfunction and reduced lifespan
Hum. Mol. Genet., January 1, 2009; 18(1): 97 - 104.
[Abstract] [Full Text] [PDF]


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Genes Dev.Home page
C. Kang and L. Avery
Systemic regulation of starvation response in Caenorhabditis elegans
Genes & Dev., January 1, 2009; 23(1): 12 - 17.
[Abstract] [Full Text] [PDF]


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GeneticsHome page
V. M. Hapiak, R. J. Hobson, L. Hughes, K. Smith, G. Harris, C. Condon, P. Komuniecki, and R. W. Komuniecki
Dual Excitatory and Inhibitory Serotonergic Inputs Modulate Egg Laying in Caenorhabditis elegans
Genetics, January 1, 2009; 181(1): 153 - 163.
[Abstract] [Full Text] [PDF]