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FEEDBACK-INSENSITIVE MUTANTS OF THE GENE FOR THE TYROSINE-INHIBITED DAHP SYNTHETASE IN YEAST
Pierre Meuris 1
1 Laboratoire de Génétique, Université Paul Sabatier, 118 route de Narbonne, 31 Toulouse, France
A yeast strain lacking the phenylalanine-sensitive DAHP synthetase exhibits a tyrosine-inhibited phenotype. Reversions from this phenotype were selected. They were the result of mutations affecting the tyrosine-sensitive DAHP synthetase which became insensitive to feedback inhibition, as shown by genetic and enzymatic studies. The feedback-insensitive mutations were located at five different sites scattered on the map of the aro4 gene.
Submitted on September 27, 1973
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