CHROMOSOME MARKERS IN MUS MUSCULUS: STRAIN DIFFERENCES IN C-BANDING

V. G. Dev ¹, D. A. Miller ¹, and O. J. Miller ¹

¹ Departments of Human Genetics and Development and of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, N.Y. 10032

The mitotic chromosomes of several inbred strains of mice and a series of F₁ hybrids have been analyzed by quinacrine staining and further characterized by the centromeric heterochromatin banding (C-banding). Inbred strains had the same amount of C-banding material on homologous chromosomes but showed variation in the amount on different chromosomes. F₁ hybrids showed characteristics of each parent and it appears that the amount of C-banding on each chromosome is a simple inherited polymorphism. In this study 12 different chromosomes could be distinguished by their C-banding, and these can be used as normal chromosome markers.

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