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GENETIC RELATIONSHIP BETWEEN ARYL HYDROCARBON HYDROXYLASE INDUCIBILITY AND CHEMICAL CARCINOGEN INDUCED SKIN ULCERATION IN MICE
P. E. Thomas 1, J. J. Hutton 2, and B. A. Taylor 3
1 Roche Institute of Molecular Biology, Nutley, New Jersey 07110
2 University of Kentucky, Lexington, Kentucky 40506
3 The Jackson Laboratory, Bar Harbor, Maine 04609
Inbred strains of mice show differential skin inflammatory reactivity following the topical application of polycyclic hydrocarbons. Strains also differ in the extent to which hepatic aryl hydrocarbon hydroxylase activity is induced by these compounds. Differential inflammatory response and hydroxylase inducibility are genetically controlled by alleles at the In and Ahh loci, respectively. Genetic analyses and strain surveys indicate that the In and Ahh loci are identical, or very closely linked.
Submitted on January 22, 1973
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