- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Farber, R. A.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Farber, R. A.
GENE DOSAGE AND THE EXPRESSION OF ELECTROPHORETIC PATTERNS IN HETEROPLOID MOUSE CELL LINES
Rosann A. Farber 1
1 Department of Genetics, University of Washington, Seattle, Washington 98195
Spontaneously transformed mouse cell lines heterozygous for electrophoretic markers have been studied to determine the relationship between gene dosage and phenotype. It is shown that a clone with an electrophoretic pattern for glucosephosphate isomerase of three bands in a ratio of 4A:4AB:1B contains three copies of chromosome 7, which carries the gene for this enzyme. A clone from a different line with a pattern of three bands in a ratio of 1A:6AB:9B for NADP-isocitrate dehydrogenase has four copies of the chromosome carrying this gene or three copies plus a rearrangement which apparently involves this chromosome. These results show that all of the alleles for each enzyme are expressed to an equal extent in these cells.
Submitted on January 23, 1973
This article has been cited by other articles:
 |
|
 |
|
  Y. H. Tan, E. L. Schneider, J. Tischfield, C. J. Epstein, and F. H. Ruddle Human Chromosome 21 Dosage: Effect on the Expression of the Interferon Induced Antiviral State Science, October 4, 1974; 186(4158): 61 - 63. [Abstract] [PDF]
|
|