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IS THE NOTCH LOCUS OF DROSOPHILA MELANOGASTER A TANDEM REPEAT? CORRELATION OF THE GENETIC MAP AND COMPLEMENTATION PATTERN OF SELECTED MUTATIONS
Geoffrey G. Foster 1
1 Department of Zoology, The University of British Columbia, Vancouver, B.C., Canada
Correlation of the complementation relationships between the Notch locus alleles fag, fano, Ax59d and nd, with their genetic map order, suggests a tandem repetition within the locus of functionally related sites. This observation is discussed in relation to two hypotheses: (1) that the Notch locus contains a tandem repeat of genetic material; and (2) that the tertiary structure of the Notch locus product has a spiral configuration.
Submitted on September 18, 1972Revised on November 10, 1972