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CHEMICAL SELECTION OF ALCOHOL DEHYDROGENASE NEGATIVE MUTANTS IN DROSOPHILA
William H. Sofer 1 and Mark A. Hatkoff 1
1 Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218
We describe a selection procedure which utilizes the vapor from an unsaturated alcohol, 1-pentene-3-ol, for the detection and isolation of mutant flies with little or no alcohol dehydrogenase activity. ADH-negative flies are unaffected by exposure to the unsaturated alcohol, but ADH positives (wild-types) die after short exposure. The technique can be used to select rare ADH-negative individuals from large populations of wild-type flies.
Submitted on May 26, 1972
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