- THIS ARTICLE
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Thirion, J. P.
- Articles by Hofnung, M.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Thirion, J. P.
- Articles by Hofnung, M.
ON SOME GENETIC ASPECTS OF PHAGE 
RESISTANCE IN E. COLI K12
J. P. Thirion 1 and M. Hofnung 1
1 Unité de Génétique Moléculaire, Départment de Biologie Moléculaire, Institut Pasteur, 25 rue du Dr Roux, Paris 15, France
Most mutations rendering E. coli K12 resistant to phage 
, map in two genetic regions malA and malB.—The malB region contains a gene lamB specifically involved in the receptor synthesis. Twenty-one independent lamB mutations studied by complementation belonged to a single cistron. This makes it very likely that lamB is monocistronic. Among the lamB mutants some are still sensitive to a host range mutant of phage . Mutations mapping in a proximal gene essential for maltose metabolism inactivate gene lamB by polarity confirming that both genes are part of the same operon. Because cases of intracistronic complementation have been found, the active lamB product may be an oligomeric protein.—Previously all resistant mutations in the malA region have been shown to map in the malT cistron. malT is believed to be a positive regulatory gene necessary for the induction of the "maltose operons" in the malA region and in the malB region of the E. coli K12 genetic map. No trans dominant malT mutation have been found. Therefore if they exist, they occur at a frequency of less than 10-8, or strongly reduce the growth rate of the mutants.
Revised on February 4, 1972
This article has been cited by other articles:
 |
|
 |
|
  M. S. Ciampi Rho-dependent terminators and transcription termination. Microbiology, September 1, 2006; 152(Pt 9): 2515 - 2528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Weitz, H. Hartman, and S. A. Levin Coevolutionary arms races between bacteria and bacteriophage PNAS, July 5, 2005; 102(27): 9535 - 9540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. B. Berlyn Linkage Map of Escherichia coli K-12, Edition 10: The Traditional Map Microbiol. Mol. Biol. Rev., September 1, 1998; 62(3): 814 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Hofnung An intelligent channel (and more) Science, January 27, 1995; 267(5197): 473 - 474. [PDF]
|
|
|
|
|
|
R. Hendrix and R. Duda Bacteriophage lambda PaPa: not the mother of all lambda phages Science, November 13, 1992; 258(5085): 1145 - 1148. [Abstract] [PDF]
|
|