Originally published as Genetics Published Articles Ahead of Print on September 7, 2009.

Genetics, Vol. 183, 1195-1199, November 2009, Copyright © 2009
doi:10.1534/genetics.109.106906

Ectopic Overproduction of a Sporulation-Specific Transcription Factor Induces Assembly of Prespore-Like Membranous Compartments in Vegetative Cells of Fission Yeast

Yukiko Nakase^*,1, Aiko Hirata, Chikashi Shimoda^* and Taro Nakamura^*,2

^* Department of Biology, Graduate School of Science, Osaka City University, Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan and Bioimaging Center, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Chiba 277-8562, Japan

² Corresponding author: Department of Biology, Graduate School of Science, Osaka City University, Sugimoto 3-3-138, Sumiyoshi-ku, Osaka 558-8585, Japan.
E-mail: taronaka{at}sci.osaka-cu.ac.jp

Mei4 is a key sporulation-specific transcription factor in fission yeast. Ectopic expression of Mei4 in vegetative cells caused formation of nucleated membranous compartments, which shared common features with normal forespore membranes, thereby perturbing nuclear division. These results suggest why expression of development-specific transcription factors must be strictly controlled.

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