- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.109.106005v1
183/2/747 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- GOOGLE SCHOLAR
- Articles by Cuevas, J. M.
- Articles by Sanjuán, R.
- PUBMED
- PubMed Citation
- Articles by Cuevas, J. M.
- Articles by Sanjuán, R.
Originally published as Genetics Published Articles Ahead of Print on August 3, 2009.
Genetics, Vol. 183, 747-749, October 2009, Copyright © 2009
doi:10.1534/genetics.109.106005
Point Mutation Rate of Bacteriophage 
X174
José M. Cuevas*,
Siobain Duffy
and
Rafael Sanjuán*,1
* Institut Cavanilles de Biodiversitat i Biologia Evolutiva and Departamento de Genética, Universitat de València, 46071 València, Spain and Department of Ecology, Evolution and Natural Resources, Rutgers University, New Brunswick, New Jersey 08901
1 Corresponding author: Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de València, P.O. Box 22085, 46071 València, Spain.
E-mail: rafael.sanjuan{at}uv.es
The point mutation rate of phage 
X174 was determined using the fluctuation test. After identifying the genetic changes associated with the selected phenotype, we obtained an estimate of 1.0 x 10–6 substitutions per base per round of copying, which is consistent with Drake's rule (0.003 mutations per genome per round of copying in DNA-based microorganisms).
 |