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Originally published as Genetics Published Articles Ahead of Print on July 6, 2009.
Genetics, Vol. 183, 403-405, September 2009, Copyright © 2009
doi:10.1534/genetics.109.103853
Is There Variation in Crossover Interference Levels Among Chromosomes From Human Males?
E. A. Housworth*,1 and
F. W. Stahl
* Mathematics, Biology, and Statistics Departments, Indiana University, Bloomington, Indiana 47405 and Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1229
1 Corresponding author: Department of Mathematics, Indiana University, Bloomington, IN 47405.
E-mail: ehouswor{at}indiana.edu
We demonstrate that recent data from human males are consistent with constant interference levels among chromosomes under the two-pathway model, whereas inappropriately fitting shape parameters of Gamma distributions to immunofluorescent interfoci distances observed on finite chromosomes generates false interpretations of higher levels of interference on shorter chromosomes. We provide appropriate statistical methodology.
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