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Originally published as Genetics Published Articles Ahead of Print on June 17, 2009.
Genetics, Vol. 182, 1345-1349, August 2009, Copyright © 2009
doi:10.1534/genetics.109.105114
Variation in Genomic Recombination Rates Among Heterogeneous Stock Mice
Beth L. Dumont*,
Karl W. Broman
and
Bret A. Payseur*,1
* Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706 and Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin 53706
1 Corresponding author: Laboratory of Genetics, University of Wisconsin-Madison, 2428 Genetics/Biotech Bldg., 425-G Henry Mall, Madison, WI 53706.
E-mail: payseur{at}wisc.edu
We used a large panel of pedigreed, genetically admixed house mice to study patterns of recombination rate variation in a leading mammalian model system. We found considerable inter-individual differences in genomic recombination rates and documented a significant heritable component to this variation. These findings point to clear variation in recombination rate among common laboratory strains, a result that carries important implications for genetic analysis in the house mouse.
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