- THIS ARTICLE
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
genetics.108.093153v1
182/3/839 most recent - Alert me when this article is cited
- Alert me if a correction is posted
- SERVICES
- Email this article to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Alert me to new issues of the journal
- Download to citation manager
- Reprints & Permissions
- CITING ARTICLES
- Citing Articles via HighWire
- Citing Articles via Google Scholar
- GOOGLE SCHOLAR
- Articles by Rogers, A. R.
- Articles by Huff, C.
- Search for Related Content
- PUBMED
- PubMed Citation
- Articles by Rogers, A. R.
- Articles by Huff, C.
Originally published as Genetics Published Articles Ahead of Print on May 11, 2009.
Genetics, Vol. 182, 839-844, July 2009, Copyright © 2009
doi:10.1534/genetics.108.093153
Linkage Disequilibrium Between Loci With Unknown Phase
Alan R. Rogers*,1 and
Chad Huff
* Department of Anthropology and Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112
1 Corresponding author: Department of Anthropology, 270 S. 1400 E., University of Utah, Salt Lake City, UT 84112.
E-mail: rogers{at}anthro.utah.edu
Linkage disequilibrium is often measured by two statistics, D and r, which can be interpreted as the covariance and the correlation between loci and across gametes. When data consist of diploid genotypes, however, gametes cannot be identified. A variety of iterative statistical methods are used in such cases, all of which assume random mating. Previous work has shown that D and r can be expressed as covariances and correlations across diploid genotypes, provided that mating is random. We show here that this result also holds approximately when mating is nonrandom. This provides a means of estimating these parameters without iteration and without assuming random mating. This estimator is nearly as accurate as the widely used EM estimator and is many times faster.
This article has been cited by other articles:
 |
|
 |
|
  J. Seger, W. A. Smith, J. J. Perry, J. Hunn, Z. A. Kaliszewska, L. L. Sala, L. Pozzi, V. J. Rowntree, and F. R. Adler Gene Genealogies Strongly Distorted by Weakly Interfering Mutations in Constant Environments Genetics, February 1, 2010; 184(2): 529 - 545. [Abstract] [Full Text] [PDF]
|
|
|