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Originally published as Genetics Published Articles Ahead of Print on March 30, 2009.
Genetics, Vol. 182, 627-630, June 2009, Copyright © 2009
doi:10.1534/genetics.108.099960
Segmental Duplications Contribute to Gene Expression Differences Between Humans and Chimpanzees
Ran Blekhman*,
Alicia Oshlack
and
Yoav Gilad*,1
* Department of Human Genetics, University of Chicago, Chicago, Illinois 60637 and Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia 3052
1 Corresponding author: Department of Human Genetics, University of Chicago, Chicago, IL 60637.
E-mail: gilad{at}uchicago.edu
In addition to specific changes in cis- and trans-regulatory elements, structural changes in the genome are hypothesized to underlie a large number of differences in gene expression between species. Accordingly, we show that species-specific segmental duplications are enriched with genes that are differentially expressed between humans and chimpanzees.
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Genetics 2009 182: NP.
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