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Originally published as Genetics Published Articles Ahead of Print on December 8, 2008.
Genetics, Vol. 181, 797-801, February 2009, Copyright © 2009
doi:10.1534/genetics.108.089276
HPL-2/HP1 Prevents Inappropriate Vulval Induction in Caenorhabditis elegans by Acting in Both HYP7 and Vulval Precursor Cells
Sonia Schott, Fabien Ramos, Vincent Coustham1 and Francesca Palladino2
Ecole Normale Superieure de Lyon, Laboratory of Molecular and Cellular Biology, UMR5239, 69007 Lyon, France
2 Corresponding author: Laboratory of Molecular and Cellular Biology, UMR5161, IFR128 Ecole Normale Superieure de Lyon, 46 allée d'Italie, 69007 Lyon, France.
E-mail: francesca.palladino{at}ens-lyon.fr
A current model for Caenorhabditis elegans vulval cell fate specification is that SynMuv genes act redundantly in the hyp7 hypodermal syncytium to repress the LIN-3/EGF inducer and prevent ectopic vulval induction of vulva precursor cells (VPCs). Here we show that the SynMuv gene hpl-2/HP1 has an additional function in VPCs, where it may act through target genes including LIN-39/Hox.
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