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Originally published as Genetics Published Articles Ahead of Print on November 17, 2008.
Genetics, Vol. 181, 331-334, January 2009, Copyright © 2009
doi:10.1534/genetics.108.095786
Loss of the Mitochondrial Nucleoid Protein, Abf2p, Destabilizes Repetitive DNA in the Yeast Mitochondrial Genome
Rey A. Sia*,1,
Stephanie Carrol*,
Lidza Kalifa
,
Christine Hochmuth*, and
Elaine A. Sia
* Department of Biological Sciences, The College at Brockport, State University of New York, Brockport, New York 14420 and Department of Biology, University of Rochester, Rochester, New York 14627-0211
1 Corresponding author: Department of Biological Sciences, The College at Brockport, State University of New York, 350 New Campus Dr., Brockport, NY 14420.
E-mail: rsia{at}brockport.edu
Loss of Abf2p, an abundant mitochondrial nucleoid-associated protein, results in increased mitochondrial frameshifts and direct-repeat mediated deletions but has no effect on the rate of mitochondrial point mutations. The instability of repeated sequences in this strain may be linked to the loss of mitochondrial DNA in abf2-
strains.
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Genetics 2009 181: NP.