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Originally published as Genetics Published Articles Ahead of Print on October 1, 2008.
Genetics, Vol. 180, 1645-1660, November 2008, Copyright © 2008
doi:10.1534/genetics.108.093351
Selective Sweep at a Quantitative Trait Locus in the Presence of Background Genetic Variation
Luis-Miguel Chevin*,
,1 and
Frédéric Hospital
* UMR de Génétique Végétale, Ferme du Moulon, 91190 Gif sur Yvette, France, Ecologie, Systématique et Evolution, UMR 8079, Université Paris-Sud, 91405 Orsay Cedex, France and INRA, UMR1236 Génétique et Diversité Animales, 78352 Jouy-en-Josas, France
1 Corresponding author: UMR 8079, Bât. 360, Université Paris-Sud, 91405 Orsay Cedex, France.
E-mail: luis-miguel.chevin{at}u-psud.fr
We model selection at a locus affecting a quantitative trait (QTL) in the presence of genetic variance due to other loci. The dynamics at the QTL are related to the initial genotypic value and to the background genetic variance of the trait, assuming that background genetic values are normally distributed, under three different forms of selection on the trait. Approximate dynamics are derived under the assumption of small mutation effect. For similar strengths of selection on the trait (i.e, gradient of directional selection β) the way background variation affects the dynamics at the QTL critically depends on the shape of the fitness function. It generally causes the strength of selection on the QTL to decrease with time. The resulting neutral heterozygosity pattern resembles that of a selective sweep with a constant selection coefficient corresponding to the early conditions. The signature of selection may also be blurred by mutation and recombination in the later part of the sweep. We also study the race between the QTL and its genetic background toward a new optimum and find the conditions for a complete sweep. Overall, our results suggest that phenotypic traits exhibiting clear-cut molecular signatures of selection may represent a biased subset of all adaptive traits.
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Genetics 2008 180: NP.
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