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Originally published as Genetics Published Articles Ahead of Print on September 9, 2008.
Genetics, Vol. 180, 715-726, October 2008, Copyright © 2008
doi:10.1534/genetics.108.090142
Domain-Specific Regulation of Recombination in Caenorhabditis elegans in Response to Temperature, Age and Sex
Jaclyn G. Y. Lim*,
,
Rachel R. W. Stine*,
,1 and
Judith L. Yanowitz*,2
* Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21218, Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218 and Department of Biology, Goucher College, Baltimore, Maryland 21204
2 Corresponding author: Carnegie Institution of Washington, 3520 San Martin Dr., Baltimore, MD 21218.
E-mail: yanowitz{at}ciwemb.edu
It is generally considered that meiotic recombination rates increase with temperature, decrease with age, and differ between the sexes. We have reexamined the effects of these factors on meiotic recombination in the nematode Caenorhabditis elegans using physical markers that encompass >96% of chromosome III. The only difference in overall crossover frequency between oocytes and male sperm was observed at 16°. In addition, crossover interference (CI) differs between the germ lines, with oocytes displaying higher CI than male sperm. Unexpectedly, our analyses reveal significant changes in crossover distribution in the hermaphrodite oocyte in response to temperature. This feature appears to be a general feature of C. elegans chromosomes as similar changes in response to temperature are seen for the X chromosome. We also find that the distribution of crossovers changes with age in both hermaphrodites and females. Our observations indicate that it is the oocytes from the youngest mothers—and not the oldest—that showed a different pattern of crossovers. Our data enhance the emerging hypothesis that recombination in C. elegans, as in humans, is regulated in large chromosomal domains.
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Genetics 2008 180: NP.
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