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Originally published as Genetics Published Articles Ahead of Print on September 9, 2008.
Genetics, Vol. 180, 1087-1093, October 2008, Copyright © 2008
doi:10.1534/genetics.108.093518
A Fundamental Relationship Between Genotype Frequencies and Fitnesses
Joseph Lachance1
Graduate Program in Genetics, Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794-5222
1 Author e-mail: joseph.lachance{at}sunysb.edu
The set of possible postselection genotype frequencies in an infinite, randomly mating population is found. Geometric mean heterozygote frequency divided by geometric mean homozygote frequency equals two times the geometric mean heterozygote fitness divided by geometric mean homozygote fitness. The ratio of genotype frequencies provides a measure of genetic variation that is independent of allele frequencies. When this ratio does not equal two, either selection or population structure is present. Within-population HapMap data show population-specific patterns, while pooled data show an excess of homozygotes.
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