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Originally published as Genetics Published Articles Ahead of Print on July 27, 2008.
Genetics, Vol. 179, 2313-2317, August 2008, Copyright © 2008
doi:10.1534/genetics.108.089052
Incorporation of Y'-Ty1 cDNA Destabilizes Telomeres in Saccharomyces cerevisiae Telomerase-Negative Mutants
Patrick H. Maxwell and M. Joan Curcio1
Laboratory of Developmental Genetics, Wadsworth Center and Department of Biomedical Sciences, University at Albany School of Public Health, Albany, New York 12201-2002
1 Corresponding author: Laboratory of Developmental Genetics, Wadsworth Center, P. O. Box 22002, Albany, NY 12201-2002.
E-mail: curcio{at}wadsworth.org
Ty1 retrotransposons in Saccharomyces cerevisiae are activated by telomere erosion. Ty1-dependent reverse transcription of mRNA from subtelomeric Y' repeats generates chimeric Y'-Ty1 cDNA. Here, we show that Y'-Ty1 cDNA is incorporated at eroding telomeres in the absence of telomerase. Telomeric incorporation of Y'-Ty1 cDNA promotes genome rearrangements.