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Originally published as Genetics Published Articles Ahead of Print on August 9, 2008.
Genetics, Vol. 179, 2213-2228, August 2008, Copyright © 2008
doi:10.1534/genetics.107.085340
A Complex Genetic Basis to X-Linked Hybrid Male Sterility Between Two Species of House Mice
Jeffrey M. Good1, Matthew D. Dean and Michael W. Nachman2
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721
2 Corresponding author: Department of Ecology and Evolutionary Biology, BioSciences West 310, 1041 E. Lowell St., University of Arizona, Tucson, AZ 85721.
E-mail: nachman{at}email.arizona.edu
The X chromosome plays a central role in the evolution of reproductive isolation, but few studies have examined the genetic basis of X-linked incompatibilities during the early stages of speciation. We report the results of a large experiment focused on the reciprocal introgression of the X chromosome between two species of house mice, Mus musculus and M. domesticus. Introgression of the M. musculus X chromosome into a wild-derived M. domesticus genetic background produced male-limited sterility, qualitatively consistent with previous experiments using classic inbred strains to represent M. domesticus. The genetic basis of sterility involved a minimum of four X-linked factors. The phenotypic effects of major sterility QTL were largely additive and resulted in complete sterility when combined. No sterility factors were uncovered on the M. domesticus X chromosome. Overall, these results revealed a complex and asymmetric genetic basis to X-linked hybrid male sterility during the early stages of speciation in mice. Combined with data from previous studies, we identify one relatively narrow interval on the M. musculus X chromosome involved in hybrid male sterility. Only a handful of spermatogenic genes are within this region, including one of the most rapidly evolving genes on the mouse X chromosome.
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Genetics 2008 179: NP.
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