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Originally published as Genetics Published Articles Ahead of Print on July 13, 2008.
Genetics, Vol. 179, 1591-1599, July 2008, Copyright © 2008
doi:10.1534/genetics.108.089300
Dissection of the Genetic Architecture of Body Weight in Chicken Reveals the Impact of Epistasis on Domestication Traits
Arnaud Le Rouzic1, José M. Álvarez-Castro2 and Örjan Carlborg2
Linnaeus Centre for Bioinformatics, Uppsala University, 751 24 Uppsala, Sweden
1 Corresponding author: Centre for Ecological and Evolutionary Synthesis, Department of Biology, P.O. Box 1066, Blindern, 0316 Oslo, Norway.
E-mail: a.p.s.lerouzic{at}bio.uio.no
In this contribution, we study the genetic mechanisms leading to differences in the observed growth patterns of domesticated White Leghorn chickens and their wild ancestor the red jungle fowl. An epistatic QTL analysis for several body-weight measures from hatch to adulthood confirms earlier findings that polymorphisms at >15 loci contribute to body-weight determination in an F2 intercross between these populations and that many loci are involved in complex genetic interactions. Here, we use a new genetic model to decompose the genetic effects of this multilocus epistatic genetic network. The results show how the functional modeling of genetic effects provides new insights into how genetic interactions in a large set of loci jointly contribute to phenotypic expression. By exploring the functional effects of QTL alleles, we show that some alleles can display temporal shifts in the expression of genetic effects due to their dependencies on the genetic background. Our results demonstrate that the effects of many genes are dependent on genetic interactions with other loci and how their involvement in the domestication process relies on these interactions.
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