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Originally published as Genetics Published Articles Ahead of Print on May 27, 2008.
Genetics, Vol. 179, 941-950, June 2008, Copyright © 2008
doi:10.1534/genetics.108.087890
The Frequency of Fitness Peak Shifts Is Increased at Expanding Range Margins Due to Mutation Surfing
Olivia J. Burton1 and Justin M. J. Travis
Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, United Kingdom
1 Corresponding author: Institute of Biological and Environmental Sciences, University of Aberdeen, Zoology Bldg., Tillydrone Ave., Aberdeen AB24 2TZ, United Kingdom.
E-mail: olivia.burton{at}abdn.ac.uk
Dynamic species' ranges, those that are either invasive or shifting in response to environmental change, are the focus of much recent interest in ecology, evolution, and genetics. Understanding how range expansions can shape evolutionary trajectories requires the consideration of nonneutral variability and genetic architecture, yet the majority of empirical and theoretical work to date has explored patterns of neutral variability. Here we use forward computer simulations of population growth, dispersal, and mutation to explore how range-shifting dynamics can influence evolution on rugged fitness landscapes. We employ a two-locus model, incorporating sign epistasis, and find that there is an increased likelihood of fitness peak shifts during a period of range expansion. Maladapted valley genotypes can accumulate at an expanding range front through a phenomenon called mutation surfing, which increases the likelihood that a mutation leading to a higher peak will occur. Our results indicate that most peak shifts occur close to the expanding front. We also demonstrate that periods of range shifting are especially important for peak shifting in species with narrow geographic distributions. Our results imply that trajectories on rugged fitness landscapes can be modified substantially when ranges are dynamic.
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