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Genetics, Vol. 179, 1125-1127, June 2008, Copyright © 2008
doi:10.1534/genetics.108.088567
Cooperative Interactions Between Pairs of Homologous Chromatids During Meiosis in Saccharomyces cerevisiae
Joshua Chang Mell*,
Kelly Komachi
,
Owen Hughes and
Sean Burgess*,1
* Genetics Graduate Group, Section of Molecular and Cellular Biology, University of California, Davis, California 95616 and Eon, Davis, California 95616
1 Corresponding author: Section of Molecular and Cellular Biology, Briggs Hall, University of California, One Shields Ave., Davis, CA 95616.
E-mail: smburgess{at}ucdavis.edu
We report a novel instance of negative interference during Saccharomyces cerevisiae meiosis, where Cre-mediated recombination between pairs of allelic loxP sites is more frequent than expected. We suggest that endogenous crossover recombination mediates cooperative pairing interactions between all four chromatids of a meiotic bivalent.